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Updated: Aug 3, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Interstitial lung disease in systemic lupus erythematosus
1William Keck School of Medicine of the University of Southern California, Department of Medicine, Los Angeles, California 90033, USA.
Systemic lupus erythematosus (SLE) can cause serious lung issues like acute lupus pneumonitis and interstitial lung disease. Early diagnosis and treatment with corticosteroids are crucial for managing these severe pulmonary manifestations in SLE patients.
Area of Science:
- Rheumatology and Pulmonology
- Immunology and Autoimmune Diseases
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease with diverse clinical presentations.
- Pulmonary involvement is a significant complication of SLE, affecting various respiratory system components.
Purpose of the Study:
- To review two critical pulmonary manifestations of SLE: acute lupus pneumonitis and diffuse interstitial lung disease.
- To emphasize the importance of timely diagnosis and management of these conditions for patient outcomes.
Main Methods:
- Review of literature on pulmonary manifestations in SLE.
- Discussion of diagnostic tools including high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs).
Main Results:
- Acute lupus pneumonitis and diffuse interstitial lung disease significantly impact SLE patient morbidity and mortality.
- HRCT and PFTs are essential for diagnosis and monitoring.
Conclusions:
- Prompt recognition and treatment of acute lupus pneumonitis and diffuse interstitial lung disease are vital in SLE management.
- High-dose corticosteroids are the primary treatment, with other immunomodulatory agents used adjunctively.
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