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Thyrotoxicosis as a predisposing factor for cerebral venous thrombosis
H J Verberne1, E Fliers, M F Prummel
1Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands. h.j.verberne@amc.uva.nl
Thyroid : Official Journal of the American Thyroid Association
|August 25, 2000
Summary
Thyroid storm, a severe thyrotoxicosis complication, can lead to cerebral venous thrombosis (CVT). This case suggests thyrotoxicosis may increase CVT risk through hypercoagulability.
Area of Science:
- Endocrinology
- Neurology
- Hematology
Background:
- Thyroid storm is a rare, life-threatening thyrotoxicosis complication.
- Neurological complications are known in thyrotoxicosis.
- Cerebral venous thrombosis (CVT) is a serious neurological event.
Observation:
- A 28-year-old woman with Graves' disease experienced thyroid storm, possibly triggered by surgery.
- She developed CVT affecting the left transverse and rectus sinuses.
- Venous infarction in the left thalamus was observed.
Findings:
- No thrombophilic abnormalities were found, except for increased factor VIII clotting activity.
- The incidence of CVT in thyrotoxicosis is significantly higher than expected.
- Thyrotoxicosis may predispose individuals to CVT via factor VIII-mediated hypercoagulability.
Implications:
- This case supports thyrotoxicosis as a potential risk factor for CVT.
- Understanding this link is crucial for managing patients with thyroid storm.
- Further research into hypercoagulability in thyrotoxicosis is warranted.