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Updated: Oct 13, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
On the use of schematic eye models to estimate retinal image quality
1Walter Reed Army Institute of Research, US Army Medical Research Detachment, Brooks Air Force Base, Texas 78235-5138, USA. liguo@aol.com
Abstract:
The optical performance of the eyes of nine vertebrate species was evaluated using optical system design techniques and schematic eye models. Essential features of eyes, including the modulation transfer function (MTF) and the MTF cutoff frequency are related to the numerical aperture of the eyes. Superior resolution for in vivo imaging of photoreceptors may be achieved by dilating the iris pupil of an eye, minimizing coherence, and using short wavelength illumination. The difference of lateral and axial resolution between a small and a large eye for imaging photoreceptors in vivo.
