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Related Experiment Videos

Genomic sequence analysis of the mouse Naip gene array.

M G Endrizzi1, V Hadinoto, J D Growney

  • 1Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Genome Research
|August 25, 2000
PubMed
Summary

The Lgn1 locus in mice influences Legionella pneumophila replication in macrophages. This difference is linked to Neuronal Apoptosis Inhibitory Protein (Naip) gene variations, particularly within the Naip4/5/6/7 family.

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Area of Science:

  • Immunology
  • Genetics
  • Microbiology

Background:

  • The Lgn1 locus in mice controls macrophage permissiveness to Legionella pneumophila.
  • Candidate genes for this phenotype are located within a cluster of Neuronal Apoptosis Inhibitory Protein (Naip) gene paralogs.
  • Previous mapping suggested Naip2 and Naip5 are key, implying limited functional overlap among Naip loci.

Purpose of the Study:

  • To investigate polymorphisms within the Naip gene array of the 129 mouse haplotype.
  • To understand the evolutionary expansion of the Naip gene family.
  • To assess potential functional overlap among Naip paralogs.

Main Methods:

  • Genomic sequencing of the 129 mouse Naip gene array.
  • Construction of an evolutionary model for Naip gene expansion.

Related Experiment Videos

  • Comparative sequence analysis of Naip paralogs.

    • Main Results:

    • The study determined the genomic sequence of a significant portion of the 129 Naip gene array.
    • An evolutionary model revealed two distinct Naip paralog families: Naip1/2/3 and Naip4/5/6/7.
    • Recent divergence and high sequence conservation were observed within the Naip4/5/6/7 family.

    Conclusions:

    • The Naip gene array has expanded from a single progenitor gene.
    • The Naip4/5/6/7 family shows recent divergence and high conservation, suggesting potential functional redundancy.
    • Understanding Naip gene evolution provides insights into host-pathogen interactions and immune responses.