Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrically stimulated detrusor myoplasty.

J G Van Savage1, G P Perez-Abadia, L G Palanca

  • 1Divisions of Pediatric Urology, and Plastic and Reconstructive Surgery, Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA.

The Journal of Urology
|August 25, 2000
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Muscle cell-derived Ccl8 is a negative regulator of skeletal muscle regeneration.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2024
Same author

Seroprevalence of trypanosomosis and associated risk factors in cattle from coast and amazonian provinces of Ecuador.

Veterinary research communications·2024
Same author

Role of Adult Tissue-Derived Pluripotent Stem Cells in Bone Regeneration.

Stem cell reviews and reports·2019
Same author

Electrical stimulation shifts healing/scarring towards regeneration in a rat limb amputation model.

Scientific reports·2019
Same author

Fermented or unfermented milk using Bifidobacterium animalis subsp. lactis HN019: Technological approach determines the probiotic modulation of mucosal cellular immunity.

Food research international (Ottawa, Ont.)·2018
Same author

Novel clinical and molecular findings in Spanish patients with naevoid basal cell carcinoma syndrome.

The British journal of dermatology·2017

Rectus detrusor myoplasty uses electrical stimulation of a rectus abdominis muscle flap to improve bladder contractility and emptying in a canine model. This technique shows promise for children with neurogenic bladder.

Area of Science:

  • Urology
  • Biomedical Engineering
  • Surgical Innovation

Background:

  • Children with spina bifida often require clean intermittent catheterization for bladder emptying.
  • Existing methods like direct nerve stimulation have limited success.
  • Neurogenic bladder leads to hyporeflexic or areflexic bladder states.

Purpose of the Study:

  • To investigate the feasibility of rectus detrusor myoplasty for achieving bladder contractility.
  • To evaluate electrical stimulation of a rectus abdominis muscle flap wrapped around the bladder.
  • To assess the potential for enhanced bladder emptying in patients with poor detrusor contractility.

Main Methods:

  • Rectus detrusor myoplasty was performed on 8 cadavers to assess feasibility.
  • A unilateral rectus abdominis muscle flap was wrapped around the bladder, preserving key neurovascular structures.

Related Experiment Videos

  • The flap was electrically stimulated in 8 dogs at varying frequencies (40, 60, 80 Hz) to measure intravesical pressure and post-void residual.

    • Main Results:

    • Electrical stimulation significantly increased intravesical pressure over baseline (p <0.05).
    • Increased intravesical pressure ranged from 35 +/- 5 cm H2O to 45 +/- 7 cm H2O with stimulation.
    • Post-void residual decreased, showing reasonable bladder emptying at tested frequencies.

    Conclusions:

    • Electrically stimulated detrusor myoplasty effectively increases intravesical pressure and promotes bladder emptying in an animal model.
    • This technique shows potential for treating children with poor detrusor contractility and neurogenic bladder.
    • Further chronic studies are underway to validate detrusor myoplasty for clinical application.