Incidence of myocardial infarctions in HIV-infected patients between 1983 and 1998: the Frankfurt HIV-cohort study

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Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
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V Rickerts1, H Brodt, S Staszewski

  • 1Klinikum der J.W. Goethe Universität Frankfurt, Med. Klinik III / Infektiologie, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany. Rickerts@em.uni-frankfurt.de

European Journal of Medical Research
|August 26, 2000
PubMed

Insights

The incidence of myocardial infarctions (MI) in HIV patients increased after the introduction of highly active antiretroviral therapy (HAART). Age over 40 and prior HAART use were significant risk factors for MI.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • HIV infection is a growing global health concern.
  • Antiretroviral therapies have significantly improved outcomes for HIV patients.
  • Potential cardiovascular complications of HIV treatment require investigation.

Purpose of the Study:

  • To determine if highly active antiretroviral therapy (HAART) is linked to a higher rate of myocardial infarctions (MI) in individuals with HIV.
  • To analyze trends in MI incidence over different treatment eras.

Main Methods:

  • Retrospective cohort study of 4993 HIV-infected patients from 1983-1998.
  • Comparison of MI incidence across four distinct antiretroviral treatment periods.
  • Univariate and multiple regression analyses to identify MI risk factors.

Main Results:

  • A significant increase in MI incidence was observed, rising from 0.86 to 3.41 per 1000 patient-years from 1983-1998 (p=0.002).
  • Factors associated with MI included age >40, prior HAART use, homosexual/bisexual HIV transmission, and prior AIDS diagnosis.
  • Age >40 and previous HAART therapy remained significant predictors in multivariate analysis.

Conclusions:

  • The introduction of HAART in this HIV-infected cohort was associated with an increased incidence of myocardial infarctions.
  • This suggests a potential link between modern antiretroviral treatment regimens and cardiovascular risk in HIV patients.
Abstract

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