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Concentrations of insulin-like growth factor (IGF)-I, -II, and IGF binding protein-4, and -5 in human bone cell
J Pfeilschifter1, I Diel, T Klöppinger
1Kliniken Bergmannsheil, Department of Internal Medicine, University of Bochum, Bochum, Germany. johannes.pfeilschifter@ruhr-uni-bochum.de
Mechanisms of Ageing and Development
|August 26, 2000
Abstract:
We examined the effects of age on the secretion of insulin-like growth factor (IGF)-I, -II, and IGF binding protein-4, and -5 in long-term bone cell cultures from 71 female donors, aged 28-79 years. Our results suggest that under basal conditions, the intrinsic capacity of human bone cells to produce these IGF components is largely preserved with age.