Epidemiology of sarcopenia
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L J Melton1, S Khosla, B L Riggs
1Department of Health Sciences Research, Mayo Clinic Rochester, Minn., USA.
Mayo Clinic Proceedings
|August 26, 2000
Abstract:
There are few epidemiological data to estimate the prevalence of sarcopenia, nor is there a standard of morbidity that defines the degree of disability and consequently the seriousness of this problem. This article reviews data on prevalence, examines different aspects of measurements, and discusses the policy ramifications of establishing a specific definition of sarcopenia.
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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01:09Changes in the Appendicular Skeleton with Age
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