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Updated: Aug 14, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
Prostatic steroid 5 alpha-reductase, an androgen metabolic gene
1Department of Biochemistry and Molecular Biology, USC School of Medicine, Los Angeles, USA.
Abstract:
Prostate cancer risk is highest in African Americans, lowest in Asians, and intermediate in Caucasians and Latinos. The data clearly suggest that environmental and genetic factors are involved. Investigation of the genetic factors suggests that allelic variation in the SRD5A2 gene is partially responsible for the striking racial and ethnic variations in risk.
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