Related Experiment Video

Updated: Jul 30, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

[Severe pneumonia caused by Bordetella bronchiseptica]

T Zuabi1, A Faivisevitz, M L Alkan

  • 1Yoseftal Hospital, Eilat.

Harefuah
|August 26, 2000
PubMed

Insights

Bordetella bronchiseptica, a rare pathogen, can cause severe pneumonia and septic shock in humans, even those who are immunocompetent. Prompt antibiotic treatment with piperacillin-tazobactam led to a positive outcome in a patient with diabetes and tuberculosis.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Pulmonology

Background:

  • Bordetella bronchiseptica is an uncommon cause of human illness, typically presenting with a pertussis-like syndrome.
  • While often associated with respiratory symptoms, it can lead to severe conditions like pneumonia and sepsis, particularly in immunocompromised individuals.

Observation:

  • A 53-year-old male patient with a history of adult-onset diabetes and treated pulmonary tuberculosis presented with lobar pneumonia.
  • The patient rapidly progressed to septic shock and adult respiratory distress syndrome.

Findings:

  • The patient's condition significantly improved following treatment with a combination of piperacillin-tazobactam.
  • This case highlights the potential severity of Bordetella bronchiseptica infections in individuals with underlying health conditions.

Implications:

  • Clinicians should consider Bordetella bronchiseptica in the differential diagnosis of severe pneumonia and sepsis, especially in patients with risk factors.
  • Effective antibiotic therapy, such as piperacillin-tazobactam, is crucial for managing severe B. bronchiseptica infections.
  • Further research may elucidate the specific mechanisms underlying B. bronchiseptica pathogenesis in diverse patient populations.

More Related Videos

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

Experimental Model to Evaluate Resolution of Pneumonia09:49

Experimental Model to Evaluate Resolution of Pneumonia

Published on: February 17, 2023

Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...