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Related Experiment Videos

T wave alternans can decrease after coronary revascularization.

M K Batur1, A Oto, Z Ider

  • 1Hacettepe University School of Medicine, Ankara, Turkey.

Angiology
|August 26, 2000
PubMed
Summary
This summary is machine-generated.

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T wave alternans (TWA), a marker for dangerous heart rhythms, is triggered by myocardial ischemia during angioplasty. Successful revascularization significantly reduces TWA, indicating improved heart function post-procedure.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Myocardial Ischemia Research

Background:

  • T wave alternans (TWA) is linked to ventricular fibrillation and life-threatening arrhythmias.
  • TWA is recognized as an intrinsic property of ischemic myocardium.
  • Percutaneous transluminal coronary angioplasty (PTCA) can induce transient myocardial ischemia.

Purpose of the Study:

  • To investigate the role of PTCA-induced myocardial ischemia in TWA development.
  • To evaluate the impact of successful revascularization on TWA.
  • To assess TWA as a potential marker during and after coronary interventions.

Main Methods:

  • Bipolar X, Y, and Z leads were recorded from 111 patients undergoing PTCA.
  • T wave alternans (TWA) signals were analyzed using the fast Fourier transformation technique in 97 patients.

Related Experiment Videos

  • Measurements were taken before, during balloon inflation, and 24 hours post-procedure.

    • Main Results:

    • TWA values (mean and peak X, Y, Z) were significantly reduced 24 hours after PTCA compared to baseline and during ischemia (p<0.01).
    • The study demonstrated a significant reduction in TWA following successful revascularization.
    • These findings confirm induced ischemia as a trigger for TWA.

    Conclusions:

    • Myocardial ischemia induced by PTCA can trigger T wave alternans.
    • Successful revascularization effectively reduces TWA, suggesting a potential role in monitoring procedural success.
    • TWA may serve as a valuable noninvasive marker for assessing the impact of ischemia and revascularization in coronary artery disease management.