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Four mono-tetrahydrofuran ring acetogenins, montanacins B-E, from Annona montana
L Q Wang1, N Nakamura, M R Meselhy
1Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
Chemical & Pharmaceutical Bulletin
|August 26, 2000
Abstract:
Four novel mono-tetrahydrofuran (THF) acetogenins, montanacins B-E (1-4), were isolated from the ethanolic extract of the leaves of Annona montana. The structures of 1-4 were established by spectroscopic methods and their absolute stereochemistries were determined by the advanced Mosher ester method. Montancins D (3) and E (4) bear a non-adjacent tetrahydropyran (THP) ring along with a THF ring and are the most unusual type of acetogenins discovered so far.