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Related Experiment Videos

Yeasts in banal external ocular inflammations.

A Romano, E Segal, R Stein

    Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
    |January 1, 1975
    PubMed
    Summary

    Yeasts, particularly Candida species, were identified as the cause of persistent eye inflammation in patients unresponsive to standard treatments. Antifungal therapies like Mycostatin were necessary for successful treatment.

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    Area of Science:

    • Ophthalmology
    • Mycology

    Background:

    • Longstanding inflammations of the outer eye and dacryocanaliculitis can be challenging to treat.
    • Antibiotic and steroid therapies are not always effective for certain ocular inflammations.

    Purpose of the Study:

    • To investigate the role of yeasts as causative agents in refractory eye inflammations.
    • To identify specific yeast species involved in these conditions.
    • To determine effective treatment strategies for yeast-induced ocular infections.

    Main Methods:

    • Yeast isolation and identification from 313 patients with chronic eye inflammation.
    • Clinical observation of superficial epithelial and subepithelial punctate keratitis.
    • Treatment assessment using Mycostatin and amphotericin B.

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    Main Results:

    • Yeasts were isolated from 53 out of 313 patients (17%).
    • Candida species, including C. albicans and C. guillermondii, were the most common isolates.
    • A specific type of keratitis was pathognomonic of yeast infection.
    • Intensive, prolonged treatment with Mycostatin or amphotericin B led to yeast eradication and inflammation cure.

    Conclusions:

    • Yeasts, especially Candida species, are significant causative agents in persistent outer eye inflammations and dacryocanaliculitis.
    • Specific punctate keratitis patterns may indicate yeast infections.
    • Antifungal agents like Mycostatin and amphotericin B are crucial for treating these refractory cases.