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Metabolism of O6-propyl and N6-propyl-carbovir in CEM cells
W B Parker1, S C Shaddix, L M Rose
1Southern Research Institute, Birmingham, AL 35205, USA.
Nucleosides, Nucleotides & Nucleic Acids
|August 26, 2000
Abstract:
The metabolism of O6-propyl-carbovir and N6-propyl-carbovir, two selective inhibitors of HIV replication, has been evaluated in CEM cells. Both compounds were phosphorylated in intact cells to carbovir-5'-triphosphate. The metabolism of these two agents was inhibited by deoxycoformycin and mycophenolic acid, but not erythro-9-(2-hydroxy-3-nonyl)adenine. No evidence of the 5'-triphosphate of either compound was detected in CEM cells.