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Synthesis of 9-(2-deoxy-beta-D-ribofuranosyl)purine-2-thione
1Biology Department, Temple University, Philadelphia, PA 19122, USA.
Nucleosides, Nucleotides & Nucleic Acids
|August 26, 2000
Abstract:
A synthesis of 9-(2-deoxy-beta-D-ribofuranosyl)purine-2-thione was performed by desulfurization of 2'-deoxy-6-thioguanine to give 2-amino-9-(2-deoxy-beta-D-ribofuranosyl)purine, diazotization with chloride replacement to give 2-chloro-9-(2-deoxy-beta-D-ribofuranosyl)purine, and the replacement of chloride with sulfur using thiolacetic acid and deacetylation.