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Synthesis and antineoplastic activity of cyclolignan aldehydes
M Gordaliza1, M A Castro, J M Miguel del Corral
1Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, E-37007-, Salamanca, Spain. mliza@gugu.usal.es
European Journal of Medicinal Chemistry
|August 26, 2000
Abstract:
Several aldehydes related to methyl 9-deoxy-9-oxo-alpha-apopicropodophyllate, a selective antitumour agent against the HT-29 colon carcinoma, have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28). All of them lacked the lactone ring but maintained their cytotoxicity at, or under, the microM level.