Spontaneous regression of vulvar intraepithelial neoplasia 2-3

To determine the background and clinical features of a group of women who experienced spontaneous regression of vulvar intraepithelial neoplasia (VIN) 2-3 before treatment was undertaken.

A retrospective review was made of the records of 14 women who experienced spontaneous regression of VIN 2-3.

The women were 15-27 years of age (median 19.5 years). Ninety-three percent were non-white. All women were seen initially in a sexual health clinic, and with one exception, all had been treated previously for genital condyloma acuminata. Four of the 14 cases were pregnancy-associated. Half of the women were asymptomatic. The transit time to regression of VIN 2-3 was 3-30 months (median 9.5 months). The median follow-up was 3 years. All lesions were multiple and pigmented.

Spontaneous regression of VIN 2-3 can occur in young women with multifocal pigmented lesions.