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Related Experiment Video

Updated: Jul 9, 2026

Intralymphatic Immunotherapy and Vaccination in Mice

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

Immunotherapy approach to allergic disease.

R B Fick¹, J A Fox, P M Jardieu

¹Genentech Inc., 1 DNA Way, South San Francisco CA 94080-4990, USA.

Immunopharmacology

|August 29, 2000

Summary

This study explores how blocking immunoglobulin E (IgE) with rhuMAb-E25 can reduce allergic responses. Phase II trials show promising safety and efficacy for treating allergic asthma.

Area of Science:

Immunology
Allergy Research
Pharmacology

Background:

Immunoglobulin E (IgE) is central to allergic disease pathogenesis.
Targeting IgE offers a rational therapeutic strategy for allergic conditions.
rhuMAb-E25 is a novel anti-IgE antibody designed to inhibit IgE function.

Purpose of the Study:

To outline the clinical safety and efficacy of rhuMAb-E25.
To describe the mechanism of action of rhuMAb-E25 in attenuating allergic responses.
To present findings from phase II studies in allergic asthma patients.

Main Methods:

Administration of rhuMAb-E25, a recombinant humanized monoclonal anti-IgE antibody.
Assessment of IgE binding to FcεRI and immune complex formation.

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Evaluation of clinical safety and efficacy in allergic asthma patients during phase II trials.

Main Results:

rhuMAb-E25 binds to IgE at the FcεRI epitope, preventing mast cell and basophil activation.
Immune complex formation effectively reduces free IgE levels.
Phase II studies demonstrated favorable safety and efficacy profiles for rhuMAb-E25 in allergic asthma.

Conclusions:

rhuMAb-E25 effectively neutralizes IgE, thereby reducing allergic inflammation.
The non-anaphylactogenic nature of rhuMAb-E25 supports its therapeutic potential.
rhuMAb-E25 represents a viable treatment option for allergic asthma.