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Semi-solid albumin solder improved mechanical properties for laser tissue welding
C B Bleustein1, C N Walker, D Felsen
1Department of Urology, New York-Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York 10021, USA.
Lasers in Surgery and Medicine
|August 29, 2000
Summary
A novel semi-solid albumin solder formulated with hydroxypropylmethylcellulose (HPMC) demonstrated superior acute and 7-day tensile strength compared to liquid or solid albumin solders and suture controls.
Area of Science:
- Biomaterials Science
- Surgical Adhesives
- Tissue Engineering
Background:
- Traditional liquid and solid albumin solders have limitations in handling and strength.
- Hydroxypropylmethylcellulose (HPMC) was investigated as a formulation agent for albumin solders.
Purpose of the Study:
- To develop and evaluate a semi-solid albumin solder with improved characteristics.
- To compare the tensile strength and healing properties of the new solder against existing options.
Main Methods:
- Tensile strength testing of liquid, semi-solid, and solid bovine serum albumin (BSA) solders on canine small bowel in vitro.
- Evaluation of long-term healing in a porcine skin model comparing semi-solid solder, liquid solder, and suture controls.
- Assessment of tensile strength and histological findings at postoperative day 7.
Main Results:
- Semi-solid albumin solder exhibited significantly higher acute tensile strength than liquid or solid solders (P < 0.05).
- At 7 days, both human serum albumin (HSA) and BSA semi-solid solders showed significantly greater tensile strength than suture controls (P < 0.05).
- No significant histological differences were observed between any solder groups in the porcine skin model.
Conclusions:
- The semi-solid albumin solder offers improved acute tensile strength and handling compared to liquid albumin solder.
- The semi-solid formulation demonstrates enhanced wound healing strength at 7 days post-application.