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Etiology and pathogenesis of rheumatic diseases of adolescence
1Department of Paediatrics, University of British Columbia, Canada.
Adolescent Medicine (Philadelphia, Pa.)
|August 29, 2000
Abstract:
The pathogenesis of SLE is multifactorial. Immune complexes, autoantibodies, and abnormal T-lymphocyte responses all play a part. Genetic predispositions are present, but not as strongly expressed as in the spondylarthropathies. Environmental agents and the effects of sex hormones also contribute.