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Related Experiment Videos

Mechanisms for ATP-dependent chromatin remodelling.

I Whitehouse1, A Flaus, K Havas

  • 1Division of Gene Regulation and Expression, The Wellcome Trust Biocentre, Department of Biochemistry, University of Dundee, Dundee DD1 5EH, Scotland, U.K.

Biochemical Society Transactions
|August 30, 2000
PubMed
Summary
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The yeast SWI-SWF complex, an ATP-dependent chromatin remodeler, can reposition nucleosomes on DNA. This nucleosome mobilization may be a general mechanism for ATP-dependent chromatin remodeling activities.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Gene Regulation

Background:

  • Gene regulation requires specific local chromatin structures for transcription.
  • ATP-dependent chromatin remodelers utilize ATP hydrolysis to modify chromatin accessibility.
  • The yeast SWI-SWF complex is a key member of ATP-dependent chromatin remodelers.

Purpose of the Study:

  • To investigate the chromatin structure-altering capabilities of the SWI-SWF complex.
  • To determine if SWI-SWF can remodel chromatin by altering nucleosome positions.

Main Methods:

  • Development of a model system to study SWI-SWF activity.
  • Analysis of SWI-SWF's effect on nucleosome positioning within chromatin.

Main Results:

Related Experiment Videos

  • The SWI-SWF complex demonstrated the ability to alter nucleosome positions along DNA.
  • Observed nucleosome mobilization is consistent with findings for other ATP-dependent remodelers.

Conclusions:

  • Nucleosome mobilization is likely a general mechanism for ATP-dependent chromatin remodeling.
  • Further investigation into the mechanisms of nucleosome movement along DNA is warranted.