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Related Experiment Videos

Nuchal translucency in multiple pregnancies.

G Monni1, M A Zoppi, R M Ibba

  • 1Department of Obstetrics and Gynecology, Prenatal and Preimplantation Genetic Diagnosis, Fetal Therapy, Ospedale Regionale per le Microcitemie, Via Jenner 09121 Cagliari, Italy. prenatalmonni@tiscalinet.it

Croatian Medical Journal
|August 30, 2000
PubMed
Summary
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Increased nuchal translucency (NT) in multiple pregnancies is linked to higher risks of chromosomal abnormalities and fetal malformations. Monochorionic twins with increased NT face a greater chance of adverse pregnancy outcomes.

Area of Science:

  • Maternal-Fetal Medicine
  • Prenatal Diagnosis
  • Genetics

Background:

  • Nuchal translucency (NT) measurement is a key first-trimester screening tool.
  • NT screening is well-established for singleton pregnancies.
  • Data on NT prevalence and significance in multiple gestations is less defined.

Purpose of the Study:

  • To determine the prevalence of increased NT (≥95th centile) in various multiple pregnancies.
  • To investigate the association between increased NT and fetal karyotype.
  • To evaluate the relationship between increased NT and pregnancy outcomes in multiple gestations.

Main Methods:

  • Ultrasound NT measurements were performed in 6,338 pregnancies (10-14 weeks).
  • Prevalence of increased NT was assessed in 115 multiple pregnancies (twins, triplets, quadruplets, quintuplets).

Related Experiment Videos

  • Singleton pregnancies (n=400) served as controls; karyotype and outcomes were analyzed.

    • Main Results:

    • Increased NT prevalence was higher in multiple pregnancies (14% dichorionic twins, 23.3% monochorionic twins) compared to singletons (4.2%).
    • Increased NT was associated with chromosomal abnormalities like trisomy 21 and fetal malformations (skeletal dysplasia, Goldenhar syndrome).
    • Monochorionic gestations with increased NT showed higher rates of adverse outcomes, including intrauterine deaths and twin-to-twin transfusion.

    Conclusions:

    • Elevated NT in multiple pregnancies signifies increased risk for chromosomal abnormalities and fetal malformations.
    • Monochorionic twin pregnancies with increased NT are at a significantly higher risk for adverse outcomes.
    • NT screening in multiple gestations aids in risk stratification and management.