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Related Experiment Videos

Interactions between hydroxypropylcelluloses and vapour/liquid water.

C Alvarez-Lorenzo1, J L Gómez-Amoza, R Martínez-Pacheco

  • 1Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|August 30, 2000
PubMed
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Hydroxypropylcelluloses (HPCs) with varying substitution levels show distinct water interactions. Lower substitution HPCs absorb more internal water, while higher substitution HPCs bind more surface water, impacting their properties.

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Physical Chemistry

Background:

  • Cellulose-based polymers, such as hydroxypropylcelluloses (HPCs), are vital in biological and technological applications.
  • Understanding water interactions (sorption and hydration) is crucial for predicting and controlling polymer properties.

Purpose of the Study:

  • To investigate the water vapor and liquid water uptake mechanisms in twelve hydroxypropylcelluloses (HPCs) with varying degrees of substitution.
  • To correlate water interaction differences with structural and physical parameters of the HPCs.

Main Methods:

  • Water vapor sorption-desorption isotherms analyzed using Young-Nelson and GAB models.
  • Differential scanning calorimetry (DSC) to assess non-freezing water content and uptake kinetics.

Related Experiment Videos

  • Isoperibol microcalorimetry to determine enthalpies of hydration/dissolution.
  • Multiple linear regression to link water uptake to polymer characteristics.

    • Main Results:

    • Young-Nelson model effectively described water vapor sorption, differentiating surface monolayer binding (higher in HPCs) and internal absorption (higher in L-HPCs).
    • All sorbed water was non-freezing. Enthalpies of hydration/dissolution were significantly higher for HPCs (-82.95 to -99.80 J g⁻¹) compared to L-HPCs (-62.86 to -71.35 J g⁻¹).
    • Lower substitution HPCs (L-HPCs) exhibited faster water uptake kinetics in compacts compared to higher substitution HPCs (HPCs).

    Conclusions:

    • Hydroxypropylcellulose water uptake is strongly influenced by the degree of substitution, particle size, and porosity.
    • Differences in substituent content, particle size, and porosity explain the observed variations in water binding and absorption capacities.
    • These findings provide critical insights for tailoring HPCs for specific applications based on their water interaction profiles.