Related Experiment Videos
[(18)F]p-MPPF: aA radiolabeled antagonist for the study of 5-HT(1A) receptors with PET
A Plenevaux1, C Lemaire, J Aerts
1Cyclotron Research Center, Liège University, Sart Tilman B.30, B-4000 Liège, Belgium. Alain.Plenevaux@ulg.ac.be
Nuclear Medicine and Biology
|August 30, 2000
Abstract:
This paper summarizes the present status of the researches conducted with [(18)F]4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-fluorobenzamido ]ethyl]-piperazine known as [(18)F]p-MPPF, a new 5-HT(1A) antagonist for the study of the serotonergic neurotransmission with positron emission tomography (PET). This includes chemistry, radiochemistry, animal data (rats, cats, and monkeys) with autoradiography and PET, human data with PET, toxicity, and metabolism.