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Molecular mechanisms of invasion by cancer cells, leukocytes and microorganisms
T Lauwaet1, M J Oliveira, M Mareel
1Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, Belgium.
Microbes and Infection
|August 30, 2000
Abstract:
Invasion is a phenotype common to cancer cells, leukocytes, parasites, bacteria and viruses, involving cell-cell adhesion, cell-matrix adhesion, proteolysis and motility. These activities are regulated by the cross talk between invaders and host. We discuss the invasion-related molecular interactions of E-cadherin, integrins, matrix metalloproteinases and the chemokine receptor RANTES.