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Updated: Aug 10, 2026

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
New method for the effective instillation of nasal drops
1Department of Otolaryngology, Edith Cavell Hospital, Peterborough. ullas@raghavan.freeserve.co.uk
Abstract:
The main cause of sinus pathology is disease in the middle meatus, therefore, unless nasal drops are deposited in this site they will not be effective. Currently, one of three standard head positions are used by patients for the instillation of nasal drops, 'head back', 'praying to Mecca', and 'Mygind's', all are uncomfortable and only one, Mygind's position, effectively deposits the drops in the middle meatus. In this paper, we review these three positions by utilizing a preserved cadaver head and conducting a simple gravitational flow study using white liquid latex as a nasal drop substitute. We also describe a new fourth 'Ragan' position, on the side, head down, that is effective in consistently delivering nasal drops into the middle meatus and should prove a most comfortable position for patients to adopt.
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