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Updated: Jul 30, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
Alcoholism treatment and medical care costs from Project MATCH
H D Holder1, R A Cisler, R Longabaugh
1Prevention Research Center, Berkeley, CA 94704, USA.
Aims:
This paper examines the costs of medical care prior to and following initiation of alcoholism treatment as part of a study of patient matching to treatment modality.
Design:
Longitudinal study with pre- and post-treatment initiation.
Measurements:
The total medical care costs for inpatient and outpatient treatment for patients participating over a span of 3 years post-treatment.
Setting:
Three treatment sites at two of the nine Project MATCH locations (Milwaukee, WI and Providence, RI).
Participants:
Two hundred and seventy-nine patients.
Intervention:
Patients were randomly assigned to one of three treatment modalities: a 12-session cognitive behavioral therapy (CBT), a four-session motivational enhancement therapy (MET) or a 12-session Twelve-Step facilitation (TSF) treatment over 12 weeks.
Findings:
Total medical care costs declined from pre- to post-treatment overall and for each modality. Matching effects independent of clinical prognosis showed that MET has potential for medical-care cost-savings. However, patients with poor prognostic characteristics (alcohol dependence, psychiatric severity and/or social network support for drinking) have better cost-savings potential with CBT and/or TSF.
Conclusions:
Matching variables have significant importance in increasing the potential for medical-care cost-reductions following alcoholism treatment.
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