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[Effect of low calcitonin doses on bone remodeling in postmenopausal women with high bone turnover rate]
C Campusano1, J M López, C Campino
1Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago-Chile.
Background:
Calcitonin is specially indicated for the treatment of osteoporosis in women that cannot receive estrogen replacement therapy or that have a high bone turnover rate.
Aim:
To study the effects of low intranasal calcitonin doses on bone remodeling in postmenopausal women with a high bone turnover.
Patients And Methods:
Forty one healthy women aged 56 +/- 6 years old, with a mean lapse after menopause of 7.6 +/- 6.5 years and with a high bone turnover rate, evidenced by an urinary hydroxyproline (mg/dl)/creatinine (g/dl) ratio of 52.4 +/- 7.2, were studied. They were randomly assigned to receive 100 or 50 U/calcitonin thrice a week during 3 months or to a control group that received placebo. All received 500 mg/day calcium carbonate. Urinary hydroxyproline/creatinine ratio was measured a 0, 15, 30, 60 and 90 days. Plasma bone fraction of alkanine phosphatases was measured at 0, 30 and 90 days.
Results:
Initial urinary hydroxyproline/creatinine ratio and plasma bone fraction of alkanine phosphatases were similar in all study groups and there was no change in these parameters during the study period.
Conclusions:
Intranasal calcitonin in doses of 100 U thrice a week or less, does not modify accelerated bone turnover in postmenopausal women.