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Human interferon therapy for herpes zoster in adults
Abstract:
Of 37 patients with herpes zoster 28 were treated with human exogenous interferon and 9 received only culture medium. The interferon was produced in leukocyte cultures and was given intramuscularly in one daily dose of 1 million units for 5-8 days. In the interferon-treated patients interferon was detectable in serum (peak level 1-5 hours after interferon injections) and in vesicle fluid, and in some patients also in urine samples. Anti-interferon antibodies were not found. Of the 28 interferon-treated patients 8 had a slight temperature increase and 4 showed a transient local reaction. In the interferon treated group of patients the duration of pain was shortened and the development of crust formation was enhanced compared with the control group.
Insights
Human exogenous interferon treatment for herpes zoster (shingles) shortened pain duration and improved crusting. Interferon was detected in patient samples, with no adverse antibody formation observed.
Area of Science:
- Virology
- Immunology
- Dermatology
Background:
- Herpes zoster (shingles) is a viral infection causing pain and rash.
- Interferon is a protein with antiviral properties.
Purpose of the Study:
- To evaluate the efficacy and safety of human exogenous interferon in treating herpes zoster.
Main Methods:
- 28 patients received daily intramuscular injections of human leukocyte interferon (1 million units/day for 5-8 days).
- 9 patients served as a control group, receiving only culture medium.
- Interferon levels in serum, vesicle fluid, and urine were monitored. Anti-interferon antibodies were assessed.
Main Results:
- Interferon was detectable in serum, vesicle fluid, and urine of treated patients.
- No anti-interferon antibodies were detected.
- Interferon treatment led to shortened pain duration and enhanced crust formation compared to controls.
- Minor side effects included transient temperature increase (8 patients) and local reactions (4 patients).
Conclusions:
- Human exogenous interferon is a potentially effective treatment for herpes zoster.
- Interferon therapy appears safe, with no significant adverse immune responses.
- Further research may explore interferon's role in managing viral skin infections.