Role of dopamine in malignant tumor growth

The regulatory role of dopamine, a monoamine neurotransmitter and/or a neurohormone in controlling the secretion of several anterior pituitary hormones, cardiovascular, and renal functions, has already been extensively used by clinicians for therapeutic purposes. In addition to these important functions of dopamine, some recent reports also indicate its novel role in regulating malignant cell proliferation and controlling immune functions in tumor-bearing animals. Therefore, in this article, we discuss all the relevant information correlating dopamine and malignant tumor growth in order to understand the host-tumor relationship at the level of a neurotransmitter and/or a neurohormone.