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Thymidine phosphorylase expression results in a decrease in apoptosis and increase in intratumoral microvessel

M Osaki¹, T Sakatani, E Okamoto

¹First Department of Pathology, Tottori University, Faculty of Medicine, Yonago, Japan.

Virchows Archiv : an International Journal of Pathology

|August 30, 2000

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Thymidine phosphorylase (dThdPase) expression in gastric cancer correlates with increased microvessels and reduced apoptosis. This suggests dThdPase may promote tumor growth and indicate a poorer prognosis in these cancers.

Area of Science:

Oncology
Molecular Biology
Cancer Research

Background:

Thymidine phosphorylase (dThdPase), also known as platelet-derived endothelial cell growth factor (PD-ECGF), is upregulated in various human carcinomas.
Elevated dThdPase expression is linked to increased intratumoral microvessel density (IMVD) and unfavorable patient prognosis.

Purpose of the Study:

To investigate the role of dThdPase in apoptosis, IMVD, and p53 expression in human gastric carcinomas.
To determine the association between dThdPase expression levels and key indicators of tumor progression.

Main Methods:

dThdPase expression was assessed in 34 early and 36 advanced gastric carcinomas.
Intratumoral microvessel density (IMVD) and apoptotic index (AI) were quantified in dThdPase-positive and dThdPase-negative tumor areas.

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Statistical analyses were performed to compare IMVD and AI between groups and to assess correlations.

Main Results:

dThdPase expression was detected in 35.3% of early and 55.6% of advanced gastric carcinomas.
Mean IMVD was significantly higher in dThdPase-positive tumors compared to dThdPase-negative tumors (P<0.05).
Mean AI was significantly higher in dThdPase-negative tumors than in dThdPase-positive tumors (P<0.05), with an inverse correlation between AI and IMVD (P<0.001).

Conclusions:

dThdPase expression in gastric carcinomas is associated with increased IMVD and decreased apoptosis.
These findings suggest that dThdPase contributes to angiogenesis and inhibits apoptosis, potentially driving gastric cancer progression.