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Updated: Aug 6, 2026

A Model of Chronic Nutrient Infusion in the Rat
Published on: August 14, 2013
Intravenous feeding of a complete diet in a child: report of a case
Insights
This study demonstrates that complete intravenous feeding can be a life-saving procedure for infants with severe malnutrition (marasmus). This nutritional support enabled successful treatment of Hirschsprung
Area of Science:
- Pediatric surgery
- Gastroenterology
- Neonatology
Background:
- Hirschsprung's disease is a congenital condition affecting the large intestine.
- Infants with Hirschsprung's disease can experience complications like digestive upset and infections.
- Severe malnutrition, or marasmus, can be life-threatening in infants.
Observation:
- A 5-month-old infant with Hirschsprung's disease presented with severe marasmus.
- The infant's condition indicated a high risk of mortality.
- The infant experienced digestive upset and an upper respiratory infection.
Findings:
- Complete intravenous feeding was administered for five days.
- The intravenous feeding included fats, carbohydrates, and amino acids.
- There was a rapid and significant improvement in the infant's nutritional status.
Implications:
- Total parenteral nutrition (TPN) can be a practical and life-saving procedure for infants.
- TPN is particularly beneficial for marasmic infants or those unable to feed orally.
- This approach can be crucial when oral intake must be withheld for therapeutic reasons.
Abstract:
A 5-month-old white infant with Hirschsprung's disease, complicated by a digestive upset and upper respiratory infection, developed a most extreme picture of marasmus which gave every indication of an impending fatal termination. The baby was given a complete intravenous feeding for five days with fats, carbohydrate, and amino acids in proportions and quantities recommended in a normal infant's diet. There was a prompt dramatic improvement in the nutrition, permitting eventual successful treatment of the Hirschsprung's disease with prostigmine. We believe that this is the first case on record of complete feeding by vein alone for a significant period of time. The success in this child suggests strongly that total feedings by vein can be a practical and lifesaving procedure, especially applicable to children who are marasmic, or are for any reason unable to handle an adequate diet by mouth, or in whom it is desirable to withhold oral feedings for therapeutic purposes.
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