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Angiotensin I converting enzyme polymorphism in humans with age-associated memory impairment: relationship with
D Bartrés-Faz1, C Junqué, I C Clemente
1Psychobiology Unit, Department of Psychiatry and Psychobiology, University of Barcelona, Passeig de la Vall d'Hebron, 171, 08035 Barcelona, Catalunya, Spain. dbartres@psi.ub.es
Abstract:
We compared the distribution of an insertion (I)/deletion (D) polymorphism coding for the angiotensin I converting enzyme (ACE) gene in 100 subjects fulfilling NIMH criteria for Age-associated memory impairment (AAMI) and 124 controls. We found significantly reduced prevalences of the ACE I/I genotype together with increases of the ACE D allele in the AAMI group. We further compared the neuropsychological performance of the AAMI group according to their ACE genotype. Those AAMI subjects presenting the ACE I/I genotype exhibited better performance on a measure of frontal lobe function. Our results suggest that the lack of the ACE I/I genotype and the presence of the ACE D allele are associated with memory impairment in the elderly.