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Predictive value of acetylcholine stimulation testing for oligohidrosis caused by zonisamide
A Okumura1, N Ishihara, T Kato
1Department of Pediatrics, Nagoya University School of Medicine, Nagoya, Aichi, Japan.
Pediatric Neurology
|August 30, 2000
Abstract:
We studied 16 patients for whom zonisamide was newly prescribed. Acetylcholine stimulation testing was performed about 1 month after zonisamide was initiated. Oligohidrosis occurred in none of the four with a normal response and in four of the 12 with a decreased response. Acetylcholine stimulation testing predicted oligohidrosis with a sensitivity of 1 and a false-positive rate of 0.67. The acetylcholine stimulation test was sensitive in detecting oligohidrosis caused by zonisamide, although the false-positive rate was high.