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Acute renal failure in sickle cell trait.

J A Frascino, H Grabstald

    Urology
    |August 1, 1975
    PubMed
    Summary

    Sickle trait can cause acute renal failure and renal vein thrombosis due to sickled red blood cells blocking kidney blood vessels. This condition, exacerbated by gram-negative bacteremia, highlights a severe complication of sickle cell disease.

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    Area of Science:

    • Nephrology
    • Hematology
    • Pathophysiology

    Background:

    • Sickle trait is a genetic condition affecting red blood cells.
    • Gram-negative bacteremia is a serious bloodstream infection.
    • Acute renal failure (ARF) involves sudden kidney function loss.

    Purpose of the Study:

    • To report a case of ARF and renal vein thrombosis in a patient with sickle trait.
    • To investigate the role of sickled erythrocytes in the observed pathology.

    Main Methods:

    • Case report analysis.
    • Clinical observation of patient symptoms and diagnosis.

    Main Results:

    • The patient presented with ARF and symptoms of renal vein thrombosis.
    • Intrarenal vaso-occlusion by sickled erythrocytes was implicated.
    • Gram-negative bacteremia was present and likely contributed to severity.

    Conclusions:

    • Sickle trait can lead to severe renal complications like ARF and renal vein thrombosis.
    • Intrarenal sickling crisis is a potential mechanism for these complications.
    • Prompt recognition and management are crucial for patients with sickle trait and infections.

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