Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Migration of intradural epidermoid matrix: embryologic implications.

S E Kountakis1, C Y Chang, W B Gormley

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Virginia Medical School, Charlottesville 22906-0008, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|August 30, 2000
PubMed
Summary

Acquired cholesteatomas arise from the first branchial groove. This study found that cerebellopontine angle epidermoid tumors also migrate like cholesteatomas, supporting a first branchial groove origin for these tumors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Helical CT versus intermittent CT fluoroscopic guidance for musculoskeletal needle biopsies: impact on radiation exposure, procedure time, diagnostic yield, and adverse events.

Skeletal radiology·2022
Same author

Clinical severity of COVID-19 with omicron variant predominance in relation to vaccination status, age, comorbidities- a single center in Selangor, Malaysia.

The Medical journal of Malaysia·2022
Same author

Cold agglutinin-mediated autoimmune haemolytic anaemia associated with COVID-19 infection: a case report.

Hong Kong medical journal = Xianggang yi xue za zhi·2022
Same author

Invasive salmonella enteritidis infection complicated by colonic perforations and pancytopenia: A case report.

The Medical journal of Malaysia·2022
Same author

Pulmonary melioidosis.

QJM : monthly journal of the Association of Physicians·2021
Same author

Peripheral T-cell lymphoma presenting with pleural effusion.

QJM : monthly journal of the Association of Physicians·2020

Area of Science:

  • Otorhinolaryngology
  • Neurosurgery
  • Developmental Biology

Background:

  • Acquired cholesteatomas, originating from the tympanic membrane, exhibit migratory behavior.
  • This migratory behavior is linked to their embryological origin from the first branchial groove.
  • Cerebellopontine angle (CPA) epidermoid tumors are of unknown embryological origin.

Observation:

  • Intradural CPA epidermoid tumor cells were cultured in vitro.
  • The migratory behavior of these cultured cells was measured daily.
  • The tissue matrix from CPA epidermoid tumors demonstrated migratory properties in the culture.

Findings:

  • The in vitro migratory properties of CPA epidermoid tumor matrix were indistinguishable from those of acquired cholesteatomas.
  • This suggests a shared migratory cellular mechanism between the two pathologies.

Related Experiment Videos

  • The observed migration supports a common embryological origin.

    • Implications:

    • These findings support the theory that intradural CPA epidermoid tumors originate from the first branchial groove.
    • This provides a potential etiological link between CPA epidermoids and congenital cholesteatomas.
    • Understanding the migratory behavior may offer insights into tumor growth and treatment strategies.