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Risk factors associated with hypothyroidism after laryngectomy.

R L Gal1, T J Gal, D W Klotch

  • 1Department of Otolaryngology, University of South Florida, Tampa 33612, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|August 30, 2000
PubMed
Summary

Hypothyroidism after laryngectomy is linked to female sex, radiation, tumor invasion, and metastases. The highest risk period for developing hypothyroidism is 0-14 months post-surgery.

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Area of Science:

  • Endocrinology
  • Oncology
  • Head and Neck Surgery

Background:

  • Hypothyroidism is a known complication following head and neck cancer treatment.
  • Laryngectomy patients are particularly susceptible to post-treatment hypothyroidism.

Purpose of the Study:

  • To identify factors associated with hypothyroidism development after laryngectomy.
  • To establish a risk factor profile for hypothyroidism in this patient group.

Main Methods:

  • Retrospective review of 136 laryngectomy patient records.
  • Cox proportional hazards model to identify risk factors.
  • Actuarial method to determine the period of greatest risk.

Main Results:

  • Female sex, preoperative radiation, thyroid gland invasion, cervical metastases, and postoperative fistula were significant risk factors.

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  • The highest risk period for hypothyroidism was estimated between 0 and 14 months post-surgery.
  • Hypothyroid patients experienced twice as many wound complications.

    • Conclusions:

    • Awareness of identified risk factors enables early recognition and management of hypothyroidism.
    • Proactive management of hypothyroidism may reduce complications like wound healing issues and fistulas.