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Related Experiment Videos

Recurrence of meningiomas.

F Yamasaki1, H Yoshioka, S Hama

  • 1Department of Neurosurgery, Hiroshima University School of Medicine, Japan.

Cancer
|August 30, 2000
PubMed
Summary

High vascular endothelial growth factor (VEGF) expression predicts recurrence in benign meningioma patients after surgery. This suggests VEGF promotes tumor regrowth through neovascularization, even after complete resection.

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Area of Science:

  • Neuro-oncology
  • Surgical oncology
  • Molecular biology

Background:

  • Benign meningiomas can recur despite complete surgical removal.
  • The precise mechanisms driving meningioma recurrence remain incompletely understood.
  • Vascular endothelial growth factor (VEGF) is implicated in tumor neovascularization.

Purpose of the Study:

  • To investigate if VEGF expression predicts recurrence in histologically benign meningiomas.
  • To identify risk factors for meningioma recurrence after macroscopic total resection.

Main Methods:

  • Analysis of 54 patients with supratentorial convexity meningiomas undergoing Simpson Grade 1 resection.
  • Statistical correlation of recurrence with factors including age, gender, tumor characteristics, MIB-1 labeling index, and VEGF expression.

Related Experiment Videos

  • Exclusion of patients with multiple meningiomas, neurofibromatosis, or atypical/anaplastic subtypes.

    • Main Results:

    • Vascular endothelial growth factor (VEGF) expression was detected in 34 of 54 patients.
    • Six meningiomas (11.1%) recurred during follow-up.
    • High VEGF expression (P = 0.005) and high MIB-1 labeling index (P = 0.039) were significant predictors of recurrence.

    Conclusions:

    • Elevated VEGF expression is a significant indicator for meningioma recurrence.
    • VEGF may promote recurrence by stimulating neovascularization from microscopic residual tumor cells.
    • Targeting VEGF could be a potential strategy to prevent meningioma regrowth.