Related Experiment Video
Updated: Oct 13, 2026
An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
Published on: July 29, 2025
Working memory control in patients with schizophrenia: a PET study during a random number generation task
E Artiges1, P Salamé, C Recasens
1Département de Recherche en Imagerie, Pharmacologie et Physiologie, Strasbourg, France.
Objective:
The authors' goal was to investigate brain regions involved in the deficiency of working memory control processes in patients with schizophrenia.
Method:
Regional cerebral blood flow was measured with positron emission tomography in eight men with stabilized schizophrenia and eight healthy men while they were performing a graded random number generation task. Twelve scans were made for each subject. Covariations between randomness of responses and regional activation were analyzed.
Results:
The pattern of covariation between randomness of responses and activation in the anterior cingulate and superior parietal regions differed between patients and healthy subjects.
Conclusions:
These results suggest a cinguloparietal dysfunction underlying the impairment of working memory control processes during a random number generation task in patients with schizophrenia.
