Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intracranial germ cell tumors.

R J Packer1, B H Cohen, K Cooney

  • 1Department of Neurology, Children's National Medical Center. Cleveland Clinic Foundation, Cleveland, Ohio, USA. rpacker@cnmc.org

The Oncologist
|August 31, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MRI Features of Histologically Diagnosed Supratentorial Primitive Neuroectodermal Tumors and Pineoblastomas in Correlation with Molecular Diagnoses and Outcomes: A Report from the Children's Oncology Group ACNS0332 Trial.

AJNR. American journal of neuroradiology·2019
Same author

Nursing teamwork in the care of older people: A mixed methods study.

Applied ergonomics·2019
Same author

Treatment of pediatric cerebral radiation necrosis: a systematic review.

Journal of neuro-oncology·2016
Same author

Research challenges in central nervous system manifestations of inborn errors of metabolism.

Molecular genetics and metabolism·2010
Same author

Remarkable oxide ion conductivity observed at low temperatures in a complex superstructured oxide.

Advanced materials (Deerfield Beach, Fla.)·2010
Same author

CNS germ cell tumor (CNSGCT) of childhood: presentation and delayed diagnosis.

Neurology·2007
Same journal

Target trial emulation studies in oncology: a comprehensive analysis.

The oncologist·2026
Same journal

Durable Response to Sotorasib in KRAS G12C-Mutant Intrahepatic Cholangiocarcinoma: A Case Report.

The oncologist·2026
Same journal

The Impact of Relative Dose Intensity on pCR in Neoadjuvant Chemotherapy of Muscle-Invasive Urothelial Cancer: a Multicentre Retrospective Study.

The oncologist·2026
Same journal

Prevalence, treatment and survival of Malignant Peripheral Nerve Sheath Tumor in the Danish neurofibromatosis type 1 population.

The oncologist·2026
Same journal

Molecular Tumor Board-Guided Osimertinib Therapy in EGFR L858R/Q701L-Mutant Lung Adenocarcinoma Supported by Functional Validation.

The oncologist·2026
Same journal

Phase 2 Dose Expansion Trial of OBI-3424, a DNA-Alkylating Prodrug, in Patients with Advanced Solid Tumors Expressing AKR1C3.

The oncologist·2026
See all related articles

Intracranial germ cell tumors (IGCTs) vary in type and prognosis. Germinomas respond well to radiation therapy, with chemotherapy potentially reducing treatment intensity for these brain tumors.

Area of Science:

  • Neuro-oncology
  • Pediatric oncology
  • Radiation oncology

Background:

  • Intracranial germ cell tumors (IGCTs) are diverse, affecting both children and adults.
  • Diagnosis often requires histology, though tumor markers like alpha-fetoprotein and beta-human chorionic gonadotropin can aid diagnosis.
  • Prognoses and management strategies differ significantly among IGCT subtypes.

Purpose of the Study:

  • To review the current understanding of intracranial germ cell tumors.
  • To discuss diagnostic approaches, including the role of tumor markers.
  • To outline management strategies and prognoses for different IGCT subtypes.

Main Methods:

  • Review of existing literature on intracranial germ cell tumors.
  • Analysis of diagnostic criteria and therapeutic outcomes.

Related Experiment Videos

  • Comparison of treatment efficacy for germinomas versus nongerminomatous germ cell tumors.

    • Main Results:

    • Germinomas demonstrate a favorable prognosis, with over 90% achieving effective treatment with radiation therapy.
    • Chemosensitivity of germinomas suggests chemotherapy can potentially reduce radiation doses.
    • Nongerminomatous germ cell tumors have a less favorable outcome; radiation alone achieves 40%-60% disease control, with chemotherapy potentially improving survival.

    Conclusions:

    • Germinomas are highly responsive to radiation therapy, and combined-modality treatment with chemotherapy may allow for reduced radiation volumes.
    • Management of nongerminomatous germ cell tumors remains challenging, with combined chemotherapy and radiation therapy offering improved survival rates.
    • Further research is needed to establish optimal radiation doses and volumes for IGCTs.