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Is tumour angiogenesis a prognostic factor in patients with colorectal cancer and no involved nodes?
1Institute of General Surgery, University of Parma, School of Medicine, Italy.
Objective:
To examine a possible association between tumour angiogenesis and conventional prognostic variables and to assess the prognostic value of the variables examined in patients with colorectal cancer, with no involved nodes.
Design:
Retrospective study.
Setting:
University hospital, Italy.
Subjects:
119 patients who had had colorectal cancers resected for cure with no involved nodes between 1985-1990.
Interventions:
The three microscopic fields with the most microvessels were identified by immunohistochemical techniques. 10 high-power fields in each area were used for the microvessel count and the mean values indicated the microvessel density.
Main Outcome Measures:
Correlation of microvessel density with conventional prognostic factors, recurrence rates, and survival.
Results:
There was a significant correlation between microvessel density and sex, women having a higher density than men (p < 0.05), but no significant correlations between density and recurrence rates or survival. Multivariate analysis did not indicate that microvessel density had a prognostic role.
Conclusion:
Microvessel density in colorectal cancer without involved nodes does not correlate with conventional prognostic factors and provides no prognostic information.
