Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatitis B immune globulin: the US experience.

T L Pruett1, R McGory

  • 1Charles O. Strickler Transplant Center, University of Virginia Health System, Charlottesville 22908, USA.

Clinical Transplantation
|August 31, 2000
PubMed
Summary

High-dose hepatitis B immune globulin (HBIg) prevents recurrence after liver transplant. However, predicting HBIg dosage and recurrence remains challenging, with viral mutations posing a risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protocolized screening and detection of occult alcohol use before and after liver transplant: Lessons learned from a quality improvement initiative.

Clinical transplantation·2023
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons Canadian Hepato-Pancreato-Biliary Society Canadian Society of Surgical Oncology Canadian Society of Colon and Rectal Surgeons: Victoria, BC Sept. 10-13, 2009.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

The evolving microenvironment of the human hepatocyte: Healthy vs. cirrhotic liver vs. isolated cells.

Tissue & cell·2020
Same author

The prognostic significance of glutamic acid decarboxylase antibodies in patients with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation.

Diabetes & metabolism·2018
Same author

PROviding Better ACcess To ORgans: A comprehensive overview of organ-access initiatives from the ASTS PROACTOR Task Force.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

Defining the Tipping Point in Surgical Performance for Laparoscopic Donor Nephrectomy Among Transplant Surgery Fellows: A Risk-Adjusted Cumulative Summation Learning Curve Analysis.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016

Area of Science:

  • Hepatology
  • Transplant Surgery
  • Immunology

Background:

  • Hepatitis B immune globulin (HBIg) use has improved liver transplantation outcomes for hepatitis B infected patients.
  • Reducing allograft infection incidence is a key benefit of HBIg therapy.

Purpose of the Study:

  • Review major US studies on HBIg in liver transplantation.
  • Analyze clinical results, failures, and identify knowledge gaps for optimal HBIg therapy.

Main Methods:

  • Review of clinical results from major US studies on HBIg use.
  • Analysis of clinical failures, including patterns of recurrence and challenges in dose prediction.

Main Results:

  • High-dose, continuous HBIg can prevent recurrence in hepatitis B virus DNA-positive patients.
  • Predicting post-transplant HBIg dose and recurrence is difficult.
  • Failure patterns include early wild-type and late mutant hepatitis B virus allograft infection, primarily in pre-transplant replicating patients.
  • Combination therapy with HBIg and lamivudine shows promise.

Conclusions:

  • HBIg is effective but challenges remain in predicting dosage and recurrence.
  • Understanding failure patterns and viral mutations is crucial.
  • Further research is needed on combination therapy strategies and immunosuppression protocols.

Related Experiment Videos