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Related Experiment Videos

Drug discrimination under two concurrent fixed-interval fixed-interval schedules.

D E McMillan1, M Li

  • 1Department of Pharmacology and Toxiology, University of Arkansas for Medical Sciences, Little Rock 72205, USA.

Journal of the Experimental Analysis of Behavior
|August 31, 2000
PubMed
Summary
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Pigeons learned to differentiate pentobarbital from saline using concurrent schedules. Other drugs like ethanol and chlordiazepoxide produced similar dose-response curves, indicating reliable drug discrimination capabilities in pigeons.

Area of Science:

  • Behavioral pharmacology
  • Animal models of drug effects
  • Operant conditioning

Background:

  • Drug discrimination studies are crucial for understanding drug mechanisms.
  • Concurrent schedules of reinforcement are used to study choice behavior.
  • Pigeons are a well-established model for behavioral pharmacology research.

Purpose of the Study:

  • To investigate pigeon drug discrimination under concurrent fixed-interval (FI) schedules with differing reinforcement frequencies.
  • To compare dose-response curves of various drugs (pentobarbital, chlordiazepoxide, ethanol, phencyclidine, methamphetamine) under these schedules.
  • To assess the reliability of drug discrimination when reinforcement rates vary.

Main Methods:

  • Pigeons were trained to discriminate pentobarbital from saline using concurrent FI 100-s/FI 200-s and FI 40-s/FI 80-s schedules.

Related Experiment Videos

  • Response patterns were analyzed on drug- and saline-biased keys.
  • Test sessions involved substituting various drugs and observing dose-dependent effects on key selection.

    • Main Results:

    • Pigeons successfully discriminated pentobarbital from saline under both concurrent schedules.
    • Pentobarbital, chlordiazepoxide, and ethanol dose-dependently increased responding on the pentobarbital-biased key.
    • Substituted drugs produced dose-response curves similar to those observed with other concurrent interval schedules.

    Conclusions:

    • Pigeons can perform drug discriminations under concurrent schedules even with modest differences in reinforcement frequency.
    • The findings support the validity of concurrent schedules for studying drug discrimination.
    • This model provides a reliable method for characterizing the behavioral effects of various psychoactive substances.