Related Experiment Video
Updated: Oct 13, 2026

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
Synthesis and antiviral properties of novel analogues of monophosphate and diphosphate bioactive forms of acyclovir
M Macchia1, G Antonelli, S Bertini
1Dipartimento di Scienze Farmaceutiche, Università di Pisa, Italy. nmacchia@farm,unipi.it
Abstract:
New analogues (compounds 6, 7 and 9) of the mono- (8) and diphosphate (10) bioactive forms of the antiherpes drug acyclovir are described. In compound 6, the monophosphate moiety of 8 was replaced by an aminosulfonyloxy group, while in compounds 7 and 9, a phosphonoacetamidoxy and an O-ethyl phosphonoacetamidoxy moiety are, respectively present instead of the diphosphate one of 10. None of the compounds synthesized proved to possess an appreciable activity on herpes simplex virus (HSV) or human immunodeficiency virus (HIV).
Related Concept Videos
Antiviral Nucleoside Inhibitors
DNA Base Pairing
Inhibitors of Viral Protein Synthesis
Inhibitors of Virion Maturation and Assembly
Inhibitors Of Virion Release
Inhibitors of Bacterial DNA Synthesis
