Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SAPHO: rare or just not recognized?

S Van Doornum1, D Barraclough, G McColl

  • 1Department of Rheumatology, Royal Melbourne Hospital, Australia.

Seminars in Arthritis and Rheumatism
|August 31, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Arterial stiffness is increased in systemic sclerosis: a cross-sectional comparison with matched controls.

Clinical and experimental rheumatology·2014
Same author

Medical teachers conceptualize a distinctive form of clinical knowledge.

Advances in health sciences education : theory and practice·2014
Same author

Primary angiitis of the central nervous system: experience of a Victorian tertiary-referral hospital.

Internal medicine journal·2012
Same author

Aberrant expression of metastasis-inducing proteins in ectopic and matched eutopic endometrium of women with endometriosis: implications for the pathogenesis of endometriosis.

Human reproduction (Oxford, England)·2011
Same author

Comparison of positive lymph node ratio with an inflammation-based prognostic score in colorectal cancer.

The British journal of surgery·2010
Same author

Differential regulation of the serotonin 1 A transcriptional modulators five prime repressor element under dual repression-1 and nuclear-deformed epidermal autoregulatory factor by chronic stress.

Neuroscience·2009
Same journal

Predictors of relapse, early escalation and 1-Year use of glucocorticoids in new-onset polymyalgia rheumatica: A prospective cohort study.

Seminars in arthritis and rheumatism·2026
Same journal

Postoperative complications and outcomes after surgical treatment for tophaceous gout: A systematic review and meta-analysis.

Seminars in arthritis and rheumatism·2026
Same journal

Autoantibody associations in patients with early diffuse cutaneous systemic sclerosis: the prospective registry of early systemic sclerosis.

Seminars in arthritis and rheumatism·2026
Same journal

Effectiveness and safety of primary thromboprophylaxis in antiphospholipid antibody carriers by serological 2023 ACR/EULAR domains.

Seminars in arthritis and rheumatism·2026
Same journal

Clustering-based stratification of fibromyalgia subtypes: A comparative analysis of medicated and non-medicated cohorts from two academic centers.

Seminars in arthritis and rheumatism·2026
Same journal

Imaging techniques for assessing the hand in systemic sclerosis: a systematic review.

Seminars in arthritis and rheumatism·2026
See all related articles

SAPHO syndrome, characterized by synovitis, acne, pustulosis, hyperostosis, and osteitis, may be underdiagnosed due to mild skin symptoms. Early diagnosis of SAPHO syndrome is crucial to prevent unnecessary tests and treatments.

Area of Science:

  • Rheumatology
  • Dermatology
  • Radiology

Background:

  • SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome links musculoskeletal and skin conditions.
  • Previously reported mainly in Europe and Japan, Australian cases remain undocumented.
  • This study details the clinical, laboratory, and radiographic features of Australian SAPHO syndrome patients.

Purpose of the Study:

  • To describe the clinical, laboratory, and radiographic characteristics of SAPHO syndrome in an Australian cohort.
  • To compare these findings with existing international literature.
  • To highlight the potential underdiagnosis of SAPHO syndrome.

Main Methods:

  • Retrospective review of patients meeting SAPHO diagnostic criteria (1990-1998).
  • Collected data included demographics, disease duration, skeletal and skin involvement, and treatment response.

Related Experiment Videos

  • Reviewed laboratory tests, radiology, and bone scintigraphy.

    • Main Results:

    • Six female patients (mean age 40) diagnosed with SAPHO syndrome.
    • Anterior chest wall hyperostosis was the primary skeletal feature.
    • Skin manifestations were less common than in other series; NSAIDs showed limited efficacy, while pamidronate improved pain in two patients.

    Conclusions:

    • SAPHO syndrome may be underrecognized, especially when skin symptoms are mild or absent.
    • Accurate diagnosis of SAPHO syndrome is essential to avoid unnecessary investigations and treatments.
    • Optimal treatment strategies for SAPHO syndrome require further investigation.