Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Caffeine versus methylphenidate and d-amphetamine in minimal brain dysfunction: a double-blind comparison.

R D Huestis, L E Arnold, D J Smeltzer

    The American Journal of Psychiatry
    |August 1, 1975
    PubMed
    Summary

    Caffeine showed minimal improvement for children with minimal brain dysfunction, unlike prescription medications. Methylphenidate and d-amphetamine significantly improved symptoms, outperforming caffeine and placebo.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Diffusion imaging markers of bipolar versus general psychopathology risk in youth at-risk.

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2018
    Same author

    Reward-related neural activity and structure predict future substance use in dysregulated youth.

    Psychological medicine·2016
    Same author

    Predicting clinical outcome from reward circuitry function and white matter structure in behaviorally and emotionally dysregulated youth.

    Molecular psychiatry·2016
    Same author

    Behavioral and emotional dysregulation trajectories marked by prefrontal-amygdala function in symptomatic youth.

    Psychological medicine·2014
    Same author

    A Fuller History of the PRITE.

    Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·2014
    Same author

    Reliability and validity of the psychiatry resident in-training examination.

    Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·2014

    Area of Science:

    • Pediatric Neurology
    • Pharmacology
    • Behavioral Science

    Background:

    • Minimal brain dysfunction (MBD) is a condition affecting children's behavior and learning.
    • Pharmacological interventions are commonly explored for managing MBD symptoms.

    Purpose of the Study:

    • To compare the efficacy of caffeine, methylphenidate, and d-amphetamine in treating MBD in children.
    • To evaluate if caffeine offers a viable alternative to stimulant medications for MBD.

    Main Methods:

    • A double-blind, crossover study design was employed.
    • Participants received caffeine, methylphenidate, d-amphetamine, and placebo in a randomized order.
    • Symptom improvement was assessed using standardized measures.

    Main Results:

    Related Experiment Videos

    • Caffeine demonstrated a slight improvement, not statistically significant compared to placebo.
    • Methylphenidate and d-amphetamine yielded significant symptom improvement.
    • Both prescription drugs were significantly more effective than caffeine.

    Conclusions:

    • Methylphenidate and d-amphetamine are effective treatments for MBD in children.
    • Pure caffeine is not a significantly effective treatment for MBD compared to placebo.
    • Differences from prior studies may be due to caffeine preparation (pure vs. whole coffee).