Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Structural insights into microtubule function.

¹Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA. ENOGALES@LBL.GOV

Annual Review of Biochemistry

|August 31, 2000

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Current outcomes when optimizing 'standard' sample preparation for single-particle cryo-EM.

Journal of microscopy·2019

Same author

Size-selective breaking of the core-shell structure of gallium nanoparticles.

Nanotechnology·2018

Same author

Preparing recombinant yeast septins and their analysis by electron microscopy.

Methods in cell biology·2016

Same author

Visible cathodoluminescence of Er ions in β-Ga(2)O(3) nanowires and microwires.

Nanotechnology·2011

Same author

Cathodoluminescence of rare earth implanted Ga2O3 and GeO2 nanostructures.

Nanotechnology·2011

Same author

Accurate modeling of single-particle cryo-EM images quantitates the benefits expected from using Zernike phase contrast.

Journal of structural biology·2011

Same journal

Lactate as a Chemical Modification on Proteins and Metabolites.

Annual review of biochemistry·2026

Same journal

Nucleocytoplasmic Transport.

Annual review of biochemistry·2026

Same journal

Packaging of Single-Stranded RNA in Viruses and Virus-Like Particles.

Annual review of biochemistry·2026

Same journal

Shaping of the Infant Gut Microbiome by Milk Oligosaccharides.

Annual review of biochemistry·2026

Same journal

Proteostasis Deregulation by Metabolism Drives the Hallmarks of Cancer.

Annual review of biochemistry·2026

Same journal

JoAnne Stubbe's Radical Path: A Story of Passion, Curiosity, and Persistence.

Annual review of biochemistry·2026

See all related articles

Microtubules, vital for cell transport and division, are precisely regulated through various mechanisms. Recent structural analyses offer new insights into microtubule function and drug interactions.

Area of Science:

Cell Biology
Biochemistry
Structural Biology

Background:

Microtubules are essential eukaryotic polymers involved in cell transport and division.
Regulation involves tubulin isotype transcription, heterodimer folding, post-translational modifications, and microtubule-associated proteins.
Precise temporal and spatial microtubule organization is crucial throughout the cell cycle.

Purpose of the Study:

To review current understanding of microtubule regulation.
To highlight insights gained from recent high-resolution structural analyses.
To discuss the implications for understanding antimitotic drug mechanisms.

Main Methods:

High-resolution structural analysis of tubulin and microtubules.
Integration of structural data with genetic, biochemical, and biophysical findings.

Related Experiment Videos

Review of existing literature on microtubule regulation.

Main Results:

Recent structural studies provide new perspectives on tubulin and microtubule organization.
Understanding microtubule dynamics and regulation is enhanced by structural insights.
Mechanisms of antimitotic drugs are better elucidated through structural data.

Conclusions:

High-resolution structural data is revolutionizing microtubule research.
A comprehensive understanding of microtubule cytoskeleton regulation is emerging.
This knowledge is critical for developing targeted therapies and understanding cellular processes.