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Related Experiment Videos

Avoiding multiple pregnancies in ART: a plea for single embryo transfer.

J Gerris1, E Van Royen

  • 1Fertility Centre Middelheim, Middelheim Hospital, Lindendreef 1, 2020 Antwerp, Belgium. jan.gerris@ocmw.antwerpen.be

Human Reproduction (Oxford, England)
|September 1, 2000
PubMed
Summary

Single embryo transfer (SET) is crucial for preventing twin pregnancies after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Identifying high-quality embryos and at-risk patients is key to successful SET implementation.

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Area of Science:

  • Reproductive Medicine
  • Embryology
  • In Vitro Fertilization (IVF)

Background:

  • Historically, replacing multiple embryos in IVF/ICSI aimed to maximize pregnancy rates but led to increased twin pregnancies.
  • Rising awareness of twin pregnancy risks and costs necessitates a shift towards single embryo transfer (SET).
  • Current challenges include accurately identifying embryos with the highest implantation potential.

Purpose of the Study:

  • To evaluate strategies for identifying high-implantation-potential embryos for single embryo transfer (SET).
  • To emphasize the importance of SET in preventing twin pregnancies in IVF/ICSI.
  • To identify patient populations at higher risk for twin pregnancies.

Main Methods:

  • Assessing embryo quality at various stages: two pronuclear (2PN), early cleavage, and blastocyst.
Keywords:
Genetics and Reproduction

Related Experiment Videos

  • Analyzing nucleoli polarity at the 2PN stage for implantation potential.
  • Evaluating morphological characteristics at days 2 and 3 post-fertilization.
  • Reviewing outcomes of blastocyst culture and SET at the early cleavage stage.

    • Main Results:

    • Nucleoli polarity at 2PN stage correlates with high implantation rates.
    • Morphological assessment identifies top-quality embryos in ~75% of IVF/ICSI cycles.
    • Early studies show SET can achieve ongoing pregnancy rates of 35% or higher.
    • Younger patients (<34 years) in early IVF/ICSI cycles are at highest risk (>80%) for twin pregnancies.

    Conclusions:

    • SET, particularly for young, first-time IVF/ICSI patients, is essential for twin pregnancy prevention.
    • Continued research into embryo and patient selection criteria for SET is needed.
    • Careful, progressive implementation of SET programs and comprehensive patient counseling are recommended.