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Related Experiment Videos

Measuring ventilatory acclimatization to hypoxia: comparative aspects.

F L Powell1, M R Dwinell, E A Aaron

  • 1Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0623, USA. fpowell@ucsd.edu

Respiration Physiology
|September 1, 2000
PubMed
Summary
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Acclimatization to hypoxia enhances the hypoxic ventilatory response (HVR) in mammals. This study explores mechanisms in rats and birds, noting pH changes and chemoreceptor complexities.

Area of Science:

  • Physiology
  • Respiratory Regulation

Background:

  • Acclimatization to hypoxia increases the hypoxic ventilatory response (HVR) in mammals.
  • Human studies show protocols can quantify HVR increase under isocapnia.
  • In rats, isocapnic HVR increases with chronic hypoxia, not due to non-specific drive effects.

Purpose of the Study:

  • To investigate the quantification and mechanisms of increased HVR during chronic hypoxia in mammals.
  • To explore the role of arterial pH changes in HVR augmentation.
  • To discuss limitations in HVR mechanism determination and assess animal models.

Main Methods:

  • Review of existing literature on HVR quantification in humans and animal models.
  • Analysis of chronic hypoxia effects on ventilatory drive and HVR in rats.

Related Experiment Videos

  • Consideration of avian models for studying reflex interactions and HVR.

    • Main Results:

    • Chronic hypoxia increases isocapnic HVR in rats, independent of non-specific ventilatory drive.
    • Arterial pH changes are predicted to increase HVR in rats, though not yet quantified.
    • Ducks exhibit time-dependent ventilation increases during chronic hypoxia, serving as a model for reflex studies.

    Conclusions:

    • Chronic hypoxia alters ventilatory motor output indices in rats.
    • Intrapulmonary CO(2) chemoreceptors in birds can complicate HVR measurements.
    • Further research is needed to fully elucidate HVR mechanisms during chronic hypoxia.