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Tensile strength of tablets containing two materials with a different compaction behaviour
B van Veen1, K van der Voort Maarschalk, G K Bolhuis
1Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands. b.van.veen@farm.rug.nl
International Journal of Pharmaceutics
|September 1, 2000
Summary
Tablet tensile strength from binary mixtures, like sodium chloride and pregelatinized starch, is not linear. Reduced interparticle bonding due to low adhesive forces causes decreased tablet strength.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Solid-state Chemistry
Background:
- Tablet tensile strength in binary mixtures often deviates from linear interpolation.
- Sodium chloride and pregelatinized starch exhibit distinct densification and relaxation behaviors.
- Understanding these deviations is crucial for optimizing tablet formulation and performance.
Purpose of the Study:
- To investigate the relationship between tensile strength and material composition in binary mixtures.
- To analyze the role of particle deformation, densification, and relaxation on tablet strength.
- To elucidate the causes of reduced interparticle bonding in mixed formulations.
Main Methods:
- Compression of binary mixtures of sodium chloride and pregelatinized starch.
- Measurement of tablet tensile strength and porosity.
- Analysis of particle yield pressure and relaxation behavior.
- Scanning Electron Microscopy (SEM) for visualizing interparticle bonding.
Main Results:
- Tablet tensile strength showed a non-linear decrease compared to linear interpolation.
- Yield pressure of binary mixtures was nearly linear, with starch yielding before sodium chloride.
- Higher tablet relaxation and extra porosity expansion indicated reduced interparticle bonding.
- SEM revealed low adhesive forces contributing to reduced bonding and strength.
Conclusions:
- Non-linear tensile strength in binary mixtures is attributed to reduced interparticle bonding.
- Starch percentage correlates with both tensile strength reduction and increased porosity expansion.
- Low adhesive forces between particles are a primary cause of decreased tablet strength.